N-phenyl-2-naphthylamine → n-Methyl-4-{[2-(naphthalen-2-ylamino)-quinazolin-6-yl]oxy}pyridine-2-carboxamide

HRID 639359

반응식

HRID 639359 반응식
[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]=[C:17](S(C)(=O)=O)[N:16]=[CH:15]3)[CH:8]=[CH:7][N:6]=1)=[O:4].[CH:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[CH:28][C:27]=1[NH:36]C1C=CC=CC=1>C(#N)C>[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]=[C:17]([NH:36][C:27]2[CH:28]=[CH:29][C:30]4[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH:26]=2)[N:16]=[CH:15]3)[CH:8]=[CH:7][N:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 8679N-phenyl-2-naphthylamineHCID 59254867N-methyl-4-(2-(methylsulfonyl)quinazolin-6-yloxy)picolinamide

생성물 1

HCID 59254846n-Methyl-4-{[2-(naphthalen-2-ylamino)-quinazolin-6-yl]oxy}pyridine-2-carboxamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
82.5 °C

실험 절차

N-methyl[4-(2-methylsulfonylquinazolin-6-yloxy)(2-pyridyl)]carboxamide 15 (1 eq) was treated with 2-naphthylaniline (2 eq) in acetonitrile (1 M) and heated at 80-85° C. The mixture was evaporated and purified on preparative chromatography to give the product.

후처리

  1. customThe mixture was evaporated
  2. custompurified on preparative chromatography
  3. customto give the product

출처 및 근거

ORD 기록
ord-283a518dea0649db9cded85a181d7430
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691866B2

연결된 노트

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