Hydrogen Bromide → 2-(3-tert-Butyl-phenylamino)-quinoxalin-6-ol

반응식

[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12]2[CH:21]=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22]C)[CH:18]=3)[N:13]=2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Br>>[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12]2[CH:21]=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([OH:22])[CH:18]=3)[N:13]=2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 59254854(3-tert-Butyl-phenyl)-(6-methoxy-quinoxalin-2-yl)-amine

생성물 1

HCID 1361450542-(3-tert-Butyl-phenylamino)-quinoxalin-6-ol

실험 절차

The mixture of (3-tert-Butyl-phenyl)-(6-methoxy-quinoxalin-2-yl)-amine and hydrobromic acid (48%) was subjected to the microwave at 140° C. for 6 mins. to yield the desired product. The mixture was neutralized with sodium bicarbonate solution and taken in ethyl acetate. The organic layer was washed with water and brine, concentrated, and purified on silica gel.

출처 및 근거

ORD 기록: ord-6820880ed5a74296870402dda3a82ecc
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07691866B2

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