1-(2-Chloroethoxy)-4-nitrobenzene → 4-(2-Chloroethoxy)aniline

HRID 639372노트

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HRID 639372 반응식
[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1>C(O)C.O=[Pt]=O.C(Cl)Cl>[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1

참가 물질

5

반응물 1

HCID 27645871-(2-Chloroethoxy)-4-nitrobenzene

생성물 1

HCID 1196994-(2-Chloroethoxy)aniline

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

36 g (0.178 Mol) of 1-(2-Chloro-ethoxy)-4-nitro-benzene is dissolved in 360 mL of ethanol and subjected to catalytic hydration at rt using PtO2 (1.5 g) as catalyst. The resulting suspension is diluted with CH2Cl2, filtered, and concentrated to approx. 150 mL. After cooling to 0° C. the crystals are filtered off, washed and dried at 60° C. under vacuum to obtain 4-(2-chloro-ethoxy)-phenylamine. Title compound: m.p.: 87-91° C.; ES-MS: 172 [M+H]+; single peak at tR=2.73 min (System 1).

후처리

  1. customsubjected to catalytic hydration at rt
  2. filtrationfiltered
  3. concentrationconcentrated to approx. 150 mL
  4. filtrationare filtered off
  5. washwashed
  6. customdried at 60° C. under vacuum

출처 및 근거

ORD 기록
ord-49fe89710516443cb85d5cc9e60bff6f
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691855B2

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