Dimethylamine → 4-[2-(Dimethylamino)ethoxy]aniline

HRID 639373노트

반응식

HRID 639373 반응식
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1.[CH3:12][NH:13][CH3:14]>[OH-].[Na+]>[CH3:12][N:13]([CH3:14])[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 1196994-(2-Chloroethoxy)aniline

생성물 1

HCID 64846554-[2-(Dimethylamino)ethoxy]aniline

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

11.15 g (0.065 Mol) of 4-(2-Chloro-ethoxy)-phenylamine is suspended in 150 mL (1.18 Mol) of dimethylamine (40% in water; Fluka 38940) and heated under stirring in a steel pressure reactor at 4 bar for 21 h. After cooling the reaction mixture is diluted with 150 mL of 2N NaOH and extracted with ethyl acetate. The combined organic layers are washed with water, dried (Na2SO4), filtered and evaporated under reduced pressure to obtain 4-(2-dimethylamino-ethoxy)-phenylamine. Title compound: ES-MS: 181 [M+H]+; single peak at tR=1.10 min (System 1).

후처리

  1. temperatureheated
  2. temperatureAfter cooling the reaction mixture
  3. extractionextracted with ethyl acetate
  4. washThe combined organic layers are washed with water
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-46ac115a262b4efd8020de82c5e98e43
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691855B2

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