(2-Benzylamino-3-nitro-6-trifluoromethyl-pyridin-4-yl)-carbamic acid ethyl ester → (3-Amino-2-benzylamino-6-trifluormethyl-pyridin-4-yl)-carbamic acid ethyl ester

HRID 639631노트

반응식

HRID 639631 반응식
[CH2:1]([O:3][C:4](=[O:27])[NH:5][C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[N:9]=[C:8]([NH:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:7]=1[N+:24]([O-])=O)[CH3:2].[H][H]>C(O)C.[Ni]>[CH2:1]([O:3][C:4](=[O:27])[NH:5][C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[N:9]=[C:8]([NH:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:7]=1[NH2:24])[CH3:2]

참가 물질

5

반응물 2

HCID 67456211(2-Benzylamino-3-nitro-6-trifluoromethyl-pyridin-4-yl)-carbamic acid ethyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 67455304(3-Amino-2-benzylamino-6-trifluormethyl-pyridin-4-yl)-carbamic acid ethyl ester수율 99.3%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

(2-benzylamino-3-nitro-6-trifluormethyl-pyridin-4-yl)-carbamic acid ethyl ester (95 mg, 0.25 mmol) was dissolved in 10 mL of ethanol and Raney Nickel (20 mg, 20% MW) was added then the reaction mixture was stirred at room temperature in a bomb under 50 PSI of hydrogen for 2 h. The mixture was filtered through arbocel and the filtrate was concentrated in vacuo to give 88 mg of the title compound as a pale green gum.

후처리

  1. filtrationThe mixture was filtered through arbocel
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-b8ecb760d2624a199279fc1a2051ad43
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691877B2

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