Sodium hydride → 4-(5-{1-[2-(2-Fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

HRID 639806노트

반응식

HRID 639806 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[N:13]=[N:12][C:11]([CH:14]([OH:16])[CH3:15])=[N:10]1.[H-].[Na+].CS([C:23]1[N:24]([CH3:34])[C:25]([C:28]2[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=2)=[N:26][N:27]=1)(=O)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[N:13]=[N:12][C:11]([CH:14]([O:16][C:23]2[N:24]([CH3:34])[C:25]([C:28]3[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=3)=[N:26][N:27]=2)[CH3:15])=[N:10]1

참가 물질

4

반응물 3

HCID 24758Sodium hydrideHCID 221514774-(4-Methyl-5-(methylsulfonyl)-4H-1,2,4-triazol-3-yl)pyridineHCID 684296401-[2-(2-fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-ethanol

생성물 1

HCID 115599484-(5-{1-[2-(2-Fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

실험 절차

The title compound is prepared from 1-[2-(2-fluoro-5-methyl-phenyl)-2H-tetrazol-5-yl]-ethanol (1 mmol), sodium hydride (1.5 mmol) and 4-(5-methanesulfonyl-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine (1.25 mmol).

출처 및 근거

ORD 기록
ord-8fa56b7b4e2d470886d9a6bcc7d065e9
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691892B2

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