Hydrochloric Acid → HCID 68547925, 화합물

HRID 639859노트

반응식

HRID 639859 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]23[CH2:15][C@@:14]2([CH2:16][O:17][CH3:18])[CH2:13][N:12]([CH3:19])[CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]23[CH2:15][C@@:14]2([CH2:16][O:17][CH3:18])[CH2:13][N:12]([CH3:19])[CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 24802847HCID 24802847, 화합물

생성물 1

HCID 68547925HCID 68547925, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

(1S,6R)-6-(3,4-dichlorophenyl)-3-methyl-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane (E12, 16 mg) was treated with hydrochloric acid 1.0M in diethyl ether (0.064 mL). 0.5 mL of diethyl ether were added and a colourless solid formed. Organic phase was removed after decantation of the solid. Colourless solid obtained as a 5:1 mixture of isomers due protonation on the nitrogen atom (16 mg).

후처리

  1. customa colourless solid formed
  2. customOrganic phase was removed after decantation of the solid
  3. customColourless solid obtained as a 5:1 mixture of isomers due protonation on the nitrogen atom (16 mg)

출처 및 근거

ORD 기록
ord-77dbcab9c8b4481aaacbf804ba142cb9
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691893B2

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