Hydrochloric Acid → HCID 68638800, 화합물

HRID 640010

반응식

HRID 640010 반응식
FC(F)(F)C(OC1C(F)=C(F)C(F)=C(F)C=1F)=O.[Cl:19][CH2:20][CH2:21][CH2:22][O:23][C:24]1[CH:33]=[C:32]2[C:27]([C:28]([NH:34][C:35]3[CH:36]=[N:37][N:38]([CH2:40][C:41](O)=[O:42])[CH:39]=3)=[N:29][CH:30]=[N:31]2)=[CH:26][CH:25]=1.N1C=CC=CC=1.[NH2:50][C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1.Cl>CN(C)C=O>[Cl:19][CH2:20][CH2:21][CH2:22][O:23][C:24]1[CH:33]=[C:32]2[C:27]([C:28]([NH:34][C:35]3[CH:36]=[N:37][N:38]([CH2:40][C:41]([NH:50][C:51]4[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=4)=[O:42])[CH:39]=3)=[N:29][CH:30]=[N:31]2)=[CH:26][CH:25]=1

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 6115AnilineHCID 4327891Pentafluorophenyl TrifluoroacetateHCID 68638745(4-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-1-yl)acetic acid

생성물 1

HCID 68638800HCID 68638800, 화합물수율 54%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Pentafluorophenyl trifluoroacetate (0.867 g, 3.10 mmol) was added dropwise, at room temperature, to a stirred suspension of (4-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-1-yl)acetic acid (0.800 g, 2.21 mmol) and pyridine (0.245 g, 3.10 mmol) in dimethylformamide (8 ml). After stirring for 5 minutes, aniline (0.412 g, 4.43 mmol) was added and the reaction mixture was stirred for 2 hours. The mixture was poured into dilute hydrochloric acid (0.2N, 25 ml) and the resultant solid filtered and then washed with water. The residue was stirred in dilute aqueous sodium hydroxide solution and filtered and the residue washed successively with water, methanol and diethylether to give 2-(4-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-1-yl)-N-phenylacetamide (0.520 g, 54% yield): MS (+ve ESI): 437 (M+H)+.

후처리

  1. stirringthe reaction mixture was stirred for 2 hours
  2. filtrationthe resultant solid filtered
  3. washwashed with water
  4. stirringThe residue was stirred in dilute aqueous sodium hydroxide solution
  5. filtrationfiltered
  6. washthe residue washed successively with water, methanol and diethylether

출처 및 근거

ORD 기록
ord-1f300c464cdb4f23aa328beff88a23fd
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691867B2

연결된 노트

불러오는 중…