Ethyl bromoacetate → 1-Piperazineacetic acid, 4-methyl-, ethyl ester

HRID 64060노트

반응식

HRID 64060 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.C([O-])([O-])=O.[K+].[K+].Br[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>CN(C=O)C>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 531671-Methylpiperazine

생성물 1

HCID 2069391-Piperazineacetic acid, 4-methyl-, ethyl ester수율 76.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 1-methylpiperazine (1 g, 8.771 mmol, 1.0 eq) in DMF were added K2CO3 (265 m g, 21.927 mmol, 2.5 eq) and ethyl 2-bromoacetate (167 mg, 13.15 mmol, 1.5 eq). The mixture was stirred at RT for 16 h and quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 76.4% yield. (1.3 g).

후처리

  1. customquenched
  2. extractionextracted as in Intermediate Example 5(a)
  3. distillationThe solvent was distilled off
  4. customto afford the product in 76.4% yield

출처 및 근거

ORD 기록
ord-d5fa8216baf24c95ae21cbdbec2565c0
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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