Ethyl bromoacetate → 1-Pyrrolidineacetic acid, ethyl ester

HRID 64065

반응식

HRID 64065 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].Br[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]>CN(C=O)C>[N:1]1([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 31268Pyrrolidine

생성물 1

HCID 2109961-Pyrrolidineacetic acid, ethyl ester수율 80%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of pyrrolidine (1.2 g, 16.3 mmol, 1.0 eq) in DMF were added K2CO3 (5.63 g, 40.7 mmol, 2.5 eq.) and ethyl 2-bromoacetate (1.73 g, 24.4 mmol, 1.5 eq.). The mixture was stirred at RT for 16 h and quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 80% yield (2 g). LC-MS (ESI): Calculated mass: 157.2; Observed mass 158.1 [M+H]+ (rt: 0.2 min).

후처리

  1. customquenched
  2. extractionextracted as in Intermediate Example 5(a)
  3. distillationThe solvent was distilled off
  4. customto afford the product in 80% yield (2 g)
  5. customObserved mass 158.1 [M+H]+ (rt: 0.2 min)

출처 및 근거

ORD 기록
ord-d8468bbddf1143b7b61002550654eaa0
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

연결된 노트

불러오는 중…