Methyl morpholine oxide → (+/-)-2-(2,3-Dihydroxypropoxy)-4-(3-fluorophenyl)-6-methoxyquinoline-3-carbonitrile

HRID 640724노트

반응식

HRID 640724 반응식
[CH2:1]([O:4][C:5]1[C:14]([C:15]#[N:16])=[C:13]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:24][CH3:25])[CH:11]=2)[N:6]=1)[CH:2]=[CH2:3].C[N+]1([O-])CC[O:30]CC1.CC(O)(C)C.C1COCC1.[OH2:44]>O.CCOC(C)=O.O=[Os](=O)(=O)=O>[OH:44][CH:2]([CH2:3][OH:30])[CH2:1][O:4][C:5]1[C:14]([C:15]#[N:16])=[C:13]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:24][CH3:25])[CH:11]=2)[N:6]=1

참가 물질

7

반응물 3

HCID 82029Methyl morpholine oxideHCID 114048472-(Allyloxy)-4-(3-fluorophenyl)-6-methoxyquinoline-3-carbonitrileHCID 22124471t-Butanol tetrahydrofuran water

생성물 1

HCID 11280099(+/-)-2-(2,3-Dihydroxypropoxy)-4-(3-fluorophenyl)-6-methoxyquinoline-3-carbonitrile

시약·촉매·용매 3

HCID 30318Osmium Tetroxide촉매HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-(allyloxy)-4-(3-fluorophenyl)-6-methoxyquinoline-3-carbonitrile (140 mg, 0.419 mmol) in 10 mL of tBuOH:THF:water (10:3:1) was added N-methylmorpholine N-oxide (49 mg, 0.42 mmol), followed by a solution of OsO4 (106 mg, 0.42 mmol) in water (ca. 0.5 mL). After stirring for 18 hours, the reaction was diluted with EtOAc, washed with saturated NaHCO3 solution, 10% citric acid solution and brine, and the organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The crude residue (144 mg) was subjected to preparative chiral HPLC through a Chiralcel OD column (85% hexanes containing 0.1% diethylamine:EtOH). The first eluting peak was collected and concentrated in vacuo to provide the titled product. 1H-NMR (500 MHz, CDCl3) δ 7.81 (d, J=9.0 Hz, 1H), 7.70 (ddd, J=8.1, 8.1, 5.6 Hz, 1H), 7.44 (dd, J=9.0, 2.9 Hz, 1H), 7.30 (ddd, J=8.6, 2.4, 1.0 Hz, 1H), 7.25 (m, 1H), 7.19 (br d, J=8.6 Hz, 1H), 6.83 (d, J=2.9 Hz, 1H), 4.68-4.76 (m, 2H), 4.19 (m, 1H), 3.84 (dd, J=11.6, 4.1 Hz, 1H), 3.79 (dd, J=11.6, 5.4 Hz, 1H), 3.74 (s, 3H) ppm. HRMS (ES) exact mass calculated for C20H18FN2O4 (M+H+): 369.1245. Found 369.1195.

후처리

  1. washwashed with saturated NaHCO3 solution, 10% citric acid solution and brine
  2. dry with materialthe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe first eluting peak was collected
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-c2756a85274c4570a2edd5682be80dbd
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07692017B2

반응 노트

불러오는 중…