1-Piperidineacetic acid, ethyl ester → Piperidin-1-yl-acetic acid

HRID 64075

반응식

HRID 64075 반응식
[N:1]1([CH2:7][C:8]([O:10]CC)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:7][C:8]([OH:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 1

HCID 6434661-Piperidineacetic acid, ethyl ester

생성물 1

HCID 201097Piperidin-1-yl-acetic acid수율 60%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

The solution of ethyl 2-(piperidin-1-yl)acetate (2.4 g, 14.0 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 60% yield (1.2 g). LC-MS (ESI): Calculated mass: 143.1; Observed mass 144.4 [M+H]+ (rt: 0.21 min).

후처리

  1. concentrationThe mixture was concentrated on vacuum pump
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 60% yield (1.2 g)
  6. customObserved mass 144.4 [M+H]+ (rt: 0.21 min)

출처 및 근거

ORD 기록
ord-fa250c7a410a424eb9b5d41a75fb6808
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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