Hydrochloric Acid → Telmisartan Hydrochloride

HRID 640750노트

반응식

HRID 640750 반응식
[CH3:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH2:12][CH3:13])[N:7]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4[C:22]([C:27]([OH:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:17][CH:16]=3)[C:6]=2[CH:5]=[C:4]([C:30]2[N:34]([CH3:35])[C:33]3[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=3[N:31]=2)[CH:3]=1.[ClH:40]>CO>[ClH:40].[CH3:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH2:12][CH3:13])[N:7]([CH2:14][C:15]3[CH:16]=[CH:17][C:18]([C:21]4[C:22]([C:27]([OH:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:19][CH:20]=3)[C:6]=2[CH:5]=[C:4]([C:30]2[N:34]([CH3:35])[C:33]3[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=3[N:31]=2)[CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 65999Telmisartan

생성물 1

HCID 11956638Telmisartan Hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

10 g of telmisartan are suspended in 70 ml of methanol in a round-bottom flask equipped with magnetic stirrer, condenser and under nitrogen atmosphere. The solution is added with 2.0 ml of a 37% HCl aqueous solution and the mixture is heated under reflux, then cooled to room temperature. The resulting precipitate is filtered and dried under vacuum at 55° C. to obtain 7.5 g of telmisartan hydrochloride.

후처리

  1. customequipped with magnetic stirrer, condenser and under nitrogen atmosphere
  2. temperaturethe mixture is heated
  3. temperatureunder reflux
  4. filtrationThe resulting precipitate is filtered
  5. customdried under vacuum at 55° C.

출처 및 근거

ORD 기록
ord-850229d9d6234a3bb62959ac022dad54
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07692027B2

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