Ethyl chloroacetate → Ethyl 2-Morpholinoacetate

HRID 64076노트

반응식

HRID 64076 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].Cl[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]>CN(C=O)C>[O:4]1[CH2:5][CH2:6][N:1]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:2][CH2:3]1

참가 물질

5

반응물 3

HCID 7751Ethyl chloroacetateHCID 8083MorpholineHCID 11430Potassium Carbonate

생성물 1

HCID 2734105Ethyl 2-Morpholinoacetate수율 73.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of morpholine (0.5 g, 5.739 mmol, 1.0 eq) in DMF were added K2CO3 (1.98 g, 14.34 mmol, 2.5 eq.) and ethyl 2-chloroacetate (1.05 g, 8.60 mmol, 1.5 eq.). The mixture was stirred at RT for 12 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 73.9% yield (0.735 g). LC-MS (ESI): Calculated mass: 173.21; Observed mass 174.0 [M+H]+ (rt: 0.1-0.4 min).

후처리

  1. customThe mixture was quenched
  2. extractionextracted as in Intermediate Example 5(a)
  3. distillationThe solvent was distilled off
  4. customto afford the product in 73.9% yield (0.735 g)
  5. customObserved mass 174.0 [M+H]+ (rt: 0.1-0.4 min)

출처 및 근거

ORD 기록
ord-bfdce75122a84f659de3c1baab96175c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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