Ethyl 2-Morpholinoacetate → 4-Morpholineacetic acid

HRID 64077노트

반응식

HRID 64077 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]CC)=[O:9])[CH2:3][CH2:2]1>Cl>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1

참가 물질

3

반응물 1

HCID 2734105Ethyl 2-Morpholinoacetate

생성물 1

HCID 4389684-Morpholineacetic acid수율 60%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

The solution of ethyl 2-morpholinoacetate (0.73 g, 4.24 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 60% yield (0.37 g). LC-MS (ESI): Calculated mass: 145.1; Observed mass 146.3 [M+H]+ (rt: 0.28 min).

후처리

  1. concentrationThe mixture was concentrated on vacuum pump
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 60% yield (0.37 g)
  6. customObserved mass 146.3 [M+H]+ (rt: 0.28 min)

출처 및 근거

ORD 기록
ord-1a70147cae1944d58500d429263efef5
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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