1-Pyrrolidineacetic acid, ethyl ester → Pyrrolidin-1-ylacetic acid

HRID 64078

반응식

HRID 64078 반응식
[N:1]1([CH2:6][C:7]([O:9]CC)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:6][C:7]([OH:9])=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 1

HCID 2109961-Pyrrolidineacetic acid, ethyl ester

생성물 1

HCID 414564Pyrrolidin-1-ylacetic acid수율 54%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

The solution of ethyl 2-(pyrrolidin-1-yl)acetate (1.8 g, 11.95 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 54% yield (1.4 g). LC-MS (ESI): Calculated mass: 129.1; Observed mass 130.1 [M+H]+ (rt: 0.26 min).

후처리

  1. concentrationThe mixture was concentrated on vacuum pump
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 54% yield (1.4 g)
  6. customObserved mass 130.1 [M+H]+ (rt: 0.26 min)

출처 및 근거

ORD 기록
ord-51539287a7fb4cb9b67dc53ad3804551
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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