1,3-Dibromo-5,5-dimethylhydantoin → 1-Bromo-3,5-dinitrobenzene

HRID 64082

반응식

HRID 64082 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=1)([O-:3])=[O:2].[Br:13]N1C(C)(C)C(=O)N(Br)C1=O>S(=O)(=O)(O)O>[Br:13][C:8]1[CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[C:6]([N+:10]([O-:12])=[O:11])[CH:7]=1

참가 물질

4

반응물 2

HCID 64791,3-Dibromo-5,5-dimethylhydantoinHCID 74521,3-Dinitrobenzene

생성물 1

HCID 445341-Bromo-3,5-dinitrobenzene수율 87%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

To a solution of 1,3-dinitrobenzene (25 g, 0.149 mol) in concentrated sulfuric acid (100 ml) at 0° C. was added 1,3-dibromo-5,5-dimethylhydantoin (31.75 g, 0.111 mol, 0.75 eq) portionwise over a period of 30 min. The mixture was stirred for 12 at RT and quenched by the addition of crushed ice. The precipitate formed was filtered and was washed repeatedly with water to obtain white solid. The solid was dried under vacuum to give the product in 87% yield (32 g).

후처리

  1. customquenched by the addition of crushed ice
  2. customThe precipitate formed
  3. filtrationwas filtered
  4. washwas washed repeatedly with water
  5. customto obtain white solid
  6. customThe solid was dried under vacuum
  7. customto give the product in 87% yield (32 g)

출처 및 근거

ORD 기록
ord-f1f8d9b2cac248a29d37c63b1939fb42
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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