Cyclopropanesulfonyl chloride → N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)cyclopropanesulfonamide

HRID 64097

반응식

HRID 64097 반응식
[CH3:1][N:2]([CH3:37])[CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:36]=[CH:35][C:13]3[N:14]([C:17]4[CH:18]=[C:19]([NH:31]C(=O)C)[CH:20]=[C:21]([C:23]5[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=5[F:30])[CH:22]=4)[CH:15]=[N:16][C:12]=3[CH:11]=2)[N:7]=[N:6]1.[CH:38]1([S:41](Cl)(=[O:43])=[O:42])[CH2:40][CH2:39]1>>[CH3:37][N:2]([CH3:1])[CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:36]=[CH:35][C:13]3[N:14]([C:17]4[CH:18]=[C:19]([NH:31][S:41]([CH:38]5[CH2:40][CH2:39]5)(=[O:43])=[O:42])[CH:20]=[C:21]([C:23]5[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=5[F:30])[CH:22]=4)[CH:15]=[N:16][C:12]=3[CH:11]=2)[N:7]=[N:6]1

참가 물질

3

반응물 2

HCID 2760919Cyclopropanesulfonyl chlorideHCID 71554232N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)acetamide

생성물 1

HCID 117777726N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)cyclopropanesulfonamide

실험 절차

The compound was prepared from the compound of Example 20 using the procedures of Example 39 and cyclopropane sulfonyl chloride. 1H NMR (400 MHz, CD3OD): δ 8.93 (s, 1H), 8.53 (s, 1H), 8.32 (s, 1H), 7.80 (d, 1H), 7.82 (d, 1H), 7.68-7.58 (m, 4H), 7.17-7.10 (m, 2H), 4.95 (t, 2H), 3.85 (t, 2H), 3.02 (s, 6H), 2.78-2.71 (m, 1H), 1.16-1.09 (m, 2H), 1.05-1.01 (m, 2H); LC-MS (ESI): Calculated mass: 563.62; Observed mass: 564.2 [M+H]+ (rt: 0.412 min).

후처리

  1. custom564.2 [M+H]+ (rt: 0.412 min)

출처 및 근거

ORD 기록
ord-273bb1d92deb441282e849a3ebb06018
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

연결된 노트

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