Sulfuric Acid → 4-(Pyrrolidin-1-YL)benzenesulfonic acid

HRID 641910

반응식

HRID 641910 반응식
[OH:1][S:2]([OH:5])(=O)=[O:3].[C:6]1([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(OCC)C>[N:12]1([C:6]2[CH:11]=[CH:10][C:9]([S:2]([OH:5])(=[O:3])=[O:1])=[CH:8][CH:7]=2)[CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 777261-Phenylpyrrolidine

생성물 1

HCID 221471014-(Pyrrolidin-1-YL)benzenesulfonic acid수율 47.2%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

반응 조건

온도
170 °C

실험 절차

A solution of H2SO4 (6.8 g, 68.00 mmol) in diethylether (80 mL) was added to 1-phenylpyrrolidine (10 g, 68.03 mmol) in diethylether (20 mL) at 0° C. The diethylether was decanted, and the resulting solution was stirred for 3 hours at 170° C., then concentrated in vacuo to afford 7.3 g (43%) of 4-(pyrrolidin-1-yl)benzenesulfonic acid as a white solid.

후처리

  1. customThe diethylether was decanted
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-fcdcf67793a74eb0b5e9c1631abd2ed2
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696229B2

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