N-Methylaniline → N-Methylacetanilide

HRID 641914

반응식

HRID 641914 반응식
O([C:5]([CH3:7])=[O:6])C(C)=O.[CH3:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH3:8][N:9]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:5](=[O:6])[CH3:7]

참가 물질

3

반응물 2

HCID 7515N-MethylanilineHCID 7918Acetic Anhydride

생성물 1

HCID 11364N-Methylacetanilide수율 73.7%

실험 절차

(CH3CO)2O (50 g, 480.77 mmol) was added to N-methylbenzenamine (10.7 g, 100.00 mmol), and the resulting solution was stirred at room temperature for 15 hours. The reaction mixture was then quenched by adding 200 mL of iced water. The resulting solution was extracted with dichloromethane (2×100 mL), and the organic layers were combined and concentrated to afford 11 g (70%) of N-methyl-N-phenylacetamide as a white solid.

후처리

  1. customThe reaction mixture was then quenched
  2. additionby adding 200 mL of iced water
  3. extractionThe resulting solution was extracted with dichloromethane (2×100 mL)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ca8bdbb9d5d249b892e411cd95f5d6d2
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696229B2

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