Methyl iodide → 5-Bromo-2-methyl-8-nitroisoquinolin-2-ium iodide
반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[I:15][CH3:16]>CN(C=O)C>[I-:15].[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][N+:6]([CH3:16])=[CH:7]2참가 물질
4
반응 조건
- 온도
- 40 °C
실험 절차
Into a 500 mL round bottom flask, was placed a solution of 5-bromo-8-nitroisoquinoline (25.59 g, 101.11 mmol) in DMF (200 mL). To the mixture was added iodomethane (71.8 g, 505.99 mmol). The resulting solution was allowed to react, with stirring, overnight while the temperature was maintained at 40° C. A filtration was performed. The filter cake was washed 2 times with 250 mL of ether. This resulted in 33.33 g (83%) of 5-bromo-8-nitro-N-methylisoquinolinium iodide as a red solid.
후처리
- customInto a 500 mL round bottom flask, was placed
- customto react
- filtrationA filtration
- washThe filter cake was washed 2 times with 250 mL of ether
- customThis resulted in 33.33 g (83%) of 5-bromo-8-nitro-N-methylisoquinolinium iodide as a red solid
출처 및 근거
- ORD 기록
- ord-39c719e9a6404df1996d34584b241dea
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07696229B2
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