Magnesium Stearate → Oxindole hydrazide

반응식

[NH2:1][NH2:2].[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][C:4]1=[O:12].[C:13]([O-:32])(=O)CCCCCCCCCCCCCCCCC.[Mg+2].C([O-])(=O)CCCCCCCCCCCCCCCCC>>[N:3]1([C:13]([NH:1][NH2:2])=[O:32])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][C:4]1=[O:12]

참가 물질

반응물 2

HCID 11177Magnesium Stearate

HCID 68408482Oxindole hydrazine

생성물 1

HCID 68409101Oxindole hydrazide

실험 절차

An oxindole hydrazine derivative of formula (I) is admixed as a dry powder with a dry gelatin binder in an approximate 1:2 weight ratio. A minor amount of magnesium stearate is added as a lubricant. The mixture is formed into 240-270 mg tablets (80-90 mg of active oxindole hydrazide compound per tablet) in a tablet press.

출처 및 근거

ORD 기록: ord-0f563ffa44e54008ba644b72f6446303
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07696231B2

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