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스테아린산 마그네슘

Magnesium Stearate

HCID 11177
새 노트새 반응견적 요청하기
인쇄 미리보기
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
557-04-0
표준 SMILES
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
InChIKey
HQKMJHAJHXVSDF-UHFFFAOYSA-L
분자식
C36H70MgO4
평균 분자량
591.2 g/mol
단동위원소 질량
590.5124524

개요

Magnesium distearate is an organic magnesium salt and a magnesium salt.

이름 및 식별자

우선 이름
Magnesium Stearate
IUPAC
magnesium bis(octadecanoate)
현지명
스테아린산 마그네슘
영어명
Magnesium stearate
분자식
C36H70MgO4
분자량
591.24

이름 및 동의어

MAGNESIUM STEARATE557-04-0Magnesium distearateMagnesium octadecanoateDibasic magnesium stearateSynpro 90Octadecanoic acid, magnesium saltStearic acid, magnesium saltPetrac MG 20NFMagnesium stearate gMagnesii stearasSynpro Magnesium Stearate 90
이름 더 보기
디베이직마그네슘스테아레이트마그네슘디스테아레이트스테아릭산,마그네슘염스테아린산마그네슘옥타데칸오익산,마그네슘염스테아린산마그네슘마그네슘스테아레이트stearatedemagnesiumMagnesium Stearate BpMAGNESIUM STEARATE N.F.Magnesium Stearate Veg. NFC4d-ADolomolAnti-C4d-Apetracmg20nfnesium stearate
NP 1500SM 1000Octadecanoic acid, magnesium salt (2:1)CHEBI:925470097M6I30DTXSID2027208DAYCLINGRefChem:5973

데이터베이스 식별자

CAS
557-04-0
PubChem CID
11177
DTXSID
DTXSID2027208
ChEMBL
CHEMBL2106633
ChEBI
CHEBI:9254
UNII
70097M6I30
EC Number
209-150-3
Nikkaji
J43.178H

물성

구조 계산 물성

극성 표면적
80.3 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
4
회전 가능 결합 수
30
무거운 원자 수
41
형식 전하
0
복잡도
196

실험 및 물리화학적 성질

Chemical Classes · 2건

Other Classes -> Stearates

Other Classes -> Stearates

Cosmetics · 2건

Cosmetic ingredients (Magnesium Stearate) -> CIR (Cosmetic Ingredient Review)

Moisturising; Cosmetic colorant; Anticaking; Bulking

Odor · 2건

Odorless

Faint, characteristic odor

TasteTasteless
Food AdditivesANTICAKING AGENT OR FREE-FLOW AGENT, DRYING AGENT, FORMULATION AID, HUMECTANT -> FDA Substance added to food
Density · 2건

1.028

1.02 g/cm³

Color/Form · 3건

LUMPS

Fine, bulky, white powder

Soft, white, light powder

Solubility · 3건

IN 100 CC WATER: 0.003 G @ 15 °C; 0.004 G @ 25 °C; 0.008 G @ 50 °C

IN 100 CC SOLVENT @ 25 °C: 0.020 G IN ALCOHOL; 0.003 G IN ETHER

Solubility in water: none

Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
Decomposition

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 54.9% (280 of 510) of all reports.

Warning

H315 (22.4%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 510 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

유해성 정보

Regulatory Information · 3건

Chemical: Octadecanoic acid, magnesium salt

Octadecanoic acid, magnesium salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Octadecanoic acid, magnesium salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Octadecanoic acid, magnesium salt: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Octadecanoic acid, magnesium salt: Human health tier I assessment
Fire HazardsCombustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.
Hazards Summary · 2건

This TLV Documentation applies only to stearic acid and magnesium, sodium, and zinc stearates. It excludes stearates of other metals. TLV Basis is lower respiratory tract irritation. No acute systemic effects of stearic acid have been reported after ingestion. . . . Sprague-Dawley rats fed stearic acid in their diet at 3000 ppm for 209 days showed 'severe pulmonary infection consisting of tracheobronchitis, lobular pneumonia, lipoid histiocytic response, and abscess formation.' [ACGIH] See Stearic acid.

화학 및 산업

용도 및 제조

Uses · 6건

CIR ingredient: Magnesium Stearate

Used in cosmetics, pharmaceuticals, food additives, waterproofing agents, plastic stabilizers, emulsifiers, and rubber lubricants and dusting agents; Stearic acid occurs naturally in human and animal fats and oils and in some vegetable oils, including cocoa oil. Stearic acid can be prepared from animal fat (triglyceride) by treating with water at high temperature, leading to hydrolysis of triglycerides, or by hydrogenation of unsaturated vegetable oils such as cottonseed oil. [ACGIH]

Used in baby dusting powders; as lubricant for plastics; as emulsifying agent in cosmetics; as drier in paints and varnishes; as flatting agent; as anticaking agent in foods and fire extinguishers; and as lubricant in making pharmaceutical tablets; [HSDB]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

IN BABY DUSTING POWDERS

Dusting powder, lubricant for plastics, emulsifying agent in cosmetics, drier in paints and varnishes and flatting agent.

Impuritiescontains small amounts of the oleate and 7% magnesium oxide. /technical grade/
U.S. Production · 4건

2023: 2,500,000 - <4,000,000 lb

(1972) 2.16X10+9 GRAMS

(1975) 1.79X10+9 GRAMS

(1984) 1.08X10+10 g

Consumer UsesFlame retardant
Industry UsesFlame retardant
Methods of ManufacturingREACTION OF SODIUM STEARATE WITH MAGNESIUM SULFATE
Formulations/Preparations · 3건

MAGNESIUM STEARATE /IS/ COMPD OF MAGNESIUM WITH MIXTURE OF SOLID ORG ACIDS OBTAINED FROM FATS, & CONSISTS CHIEFLY OF VARIABLE PROPORTIONS OF MAGNESIUM STEARATE & MAGNESIUM PALMITATE. IT CONTAINS EQUIVALENT OF 6.8-8.0% OF MAGNESIUM OXIDE (40.30).

GRADES: TECHNICAL, USP FCC.

A TYPICAL DRY COMPRESSED ANTIPERSPIRANT STICK/CONTAINS/0.25 wt% MAGNESIUM STEARATE

관련 반응

19건
반응 기록 만들기
HRID 68194 반응식
HRID 68194반응물로uspto-grants-2014_09
HRID 68195 반응식
HRID 68195반응물로uspto-grants-2014_09
HRID 381198 반응식
HRID 381198반응물로uspto-grants-2001_10
HRID 408059 반응식
HRID 408059반응물로uspto-grants-2014_06
HRID 486322 반응식
HRID 486322생성물로uspto-grants-1994_03
HRID 500290 반응식
HRID 500290반응물로uspto-grants-2010_08
HRID 642174 반응식
HRID 642174반응물로uspto-grants-2010_04
HRID 716609 반응식
HRID 716609반응물로uspto-grants-2015_11
1 / 3 페이지

화합물 노트

불러오는 중…

이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
더보기
새 노트새 반응견적 요청하기
When heated to decomposition it emits acrid smoke and toxic fumes.
Melting Point · 3건

88.5 °C (pure)

MP: 132 °C /Technical/

88 °C

Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

물리화학적 성질

녹는점
200 °C · 200 °C (lit.)
밀도
1.028 g/cm3 · 1.028g/cm3
저장 조건
Inert atmosphere,Room Temperature
용해도
알코올: 불용성
물리적 상태
고운 가루
색상
하얀색
수소이온지수(pH)
7 · 7 (H2O) (slurry)
냄새
하얀색. 부드러운 기름진 가루. 맛도 없고 냄새도 없다.
수용성
불용성
Merck
14 · 14,5690
BRN
3919702 · 3919702
안정성
안정적인. 강한 산화제와 호환되지 않습니다.
주요 응용
의약품(소분자)
화장품 원료 기능
보습고결방지제필러색소
InChI
1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
InChIKey
DRJIJXNWSSRTTE-UHFFFAOYSA-M
SMILES
CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
LogP
8.216 · 8.216 (est)
EPA
Magnesium stearate (557-04-0)
화학적 성질 · 1건

Magnesium stearate is a very fine, light white, precipitated or milled, impalpable powder of low bulk density, having a faint odor of stearic acid and a characteristic taste. The powder is greasy to the touch and readily adheres to the skin. nonflammable used in baby dusting powder(s) and as tablet lubricant.

No listed effects of short-term or long-term exposure; [ICSC] Mildly toxic by ingestion; [HSDB] May cause irritation; [MSDSonline] See STEARATES.

FDA Requirements · 2건

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

An ingredient whose use in food or food packaging is subject to a prior sanction or approval within the meaning of section 201(s)(4) of the Act is exempt from classification as a food additive. ... Substances classified as stabilizers, when migrating from food-packaging material shall include: magnesium stearate.

EPA Safer ChemicalChemical: Magnesium stearate
FIFRA Requirements · 1건

Residues of magnesium stearate are exempted from the requirement of a tolerance when used as a surfactant in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Chemical DangersDecomposes on burning. This produces irritating fumes.
Physical DangersDust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.
Other Hazardous ReactionsSpontaneously combustible.
Hazard Classes and Categories · 2건

Skin Irrit. 2 (22.4%)

Skin corrosion/irritation - Category 3

안전 및 보호

Fire FightingIn case of fire in the surroundings, use appropriate extinguishing media.
First Aid Measures · 3건

Fresh air, rest.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Rest.

Disposal Methods · 1건

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Spillage DisposalSweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.
Eye PreventionWear safety spectacles.
Fire PreventionNO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.
Inhalation RiskA nuisance-causing concentration of airborne particles can be reached quickly when dispersed.
Skin PreventionProtective gloves.
Exposure PreventionPREVENT DISPERSION OF DUST!
Allowable Tolerances · 1건

Residues of magnesium stearate are exempted from the requirement of a tolerance when used as a surfactant in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Ingestion PreventionDo not eat, drink, or smoke during work. Wash hands before eating.
Inhalation PreventionUse local exhaust.

독성 정보

Adverse Effects · 2건

ACGIH Carcinogen - Not Classifiable.

ACGIH Carcinogen - Not Classifiable.

Exposure RoutesThe substance can be absorbed into the body by inhalation.
Toxicity Summary · 2건

The CIR Expert Panel concluded that the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating and non-sensitizing, which may be based on a QRA...Magnesium Stearate

Safe for use in cosmetics, with qualifications

Signs and Symptoms · 2건

Cough.

Vomiting.

Human Toxicity Excerpts · 2건

/HUMAN EXPOSURE STUDIES/ ...DEATHS HAVE BEEN CAUSED BY ACCIDENTAL INHALATION OF THE /BABY DUSTING/ POWDER, /CONTAINING MAGNESIUM STEARATE/.

/HUMAN EXPOSURE STUDIES/ Slightly toxic by ingestion.

Non-Human Toxicity Excerpts · 1건

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Magnesium stearate was fed to groups of 20 male and 20 female rats at levels of 0, 5, 10 and 20% in a semisynthetic diet for 3 months. Decreased weight gain was found in males in the 20% group. Urolithiasis was found in 8 males and in 7 females in the same group. Reduced relative liver weight was seen in males in the 10% and in the 20% groups, and an increased amount of iron was found in the livers of the 20% group. Nephrocalcinosis was reduced in females in the 20% group. In this experiment the no-effect-level is estimated to be 5% magnesium stearate in the diet, corresponding to 2,500 mg/kg bw/day.

Evidence for CarcinogenicityA4; Not classifiable as a human carcinogen. /Stearates; does not include stearates of toxic metals/

규제 정보

FDA Requirements · 2건

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

An ingredient whose use in food or food packaging is subject to a prior sanction or approval within the meaning of section 201(s)(4) of the Act is exempt from classification as a food additive. ... Substances classified as stabilizers, when migrating from food-packaging material shall include: magnesium stearate.

FIFRA Requirements · 1건

Residues of magnesium stearate are exempted from the requirement of a tolerance when used as a surfactant in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

안전 데이터

wgk
-
tsca
TSCA listed
rtecs
WI4390000
독성
LD50 orally in Rabbit: > 2000 mg/kg
HS 번호
29157030
risk_code
36/37/38
hazard_code
Xi
safety_code
26-37/39
기존화학 물질
KE-26390
스토리지 클래스
11 - Combustible Solids
유해 물질 데이터
557-04-0(Hazardous Substances Data)
Household Products
Information on 42 consumer products that contain Magnesium stearate in the following categories is provided:
Use Classification · 4건

EPA Safer Chemical Functional Use Classes -> Surfactants

Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern

Food Additives -> ANTICAKING_AGENT; EMULSIFIER; Food Additives -> -> JECFA Functional Classes

Cosmetics -> Moisturising; Cosmetic colorant; Anticaking; Bulking

General Manufacturing Information · 4건

Plastics Material and Resin Manufacturing

Octadecanoic acid, magnesium salt (2:1): ACTIVE

The more important dusting powders include ... magnesium stearate, NF ...

Microspheres containing the mucoadhesive polymer chitosan hydrochloride, with matrix polymer Eudragit RS, pipemidic acid as a model drug and agglomeration preventing agent magnesium stearate were prepared by the solvent evaporation method. The amount of magnesium stearate was varied and the following methods were used for microsphere evaluation: sieve analysis, drug content and dissolution determination, scanning electron microscopy, x-ray diffractometry, DSC and FTIR spectroscopy. The results showed that average particle size decreased with increasing amount of magnesium stearate used for microsphere preparation. This is probably a consequence of stabilization of the emulsion droplets with magnesium stearate. Higher pipemidic acid content in the microspheres was observed in larger particle size fractions and when higher amounts of magnesium stearate were used. It was also found that these two parameters significantly influenced the dissolution rate. The important reason for the differences in drug content in microspheres of different particle sizes is the diffusion of pipemidic acid from the acetone droplets in liquid paraffin during the preparation procedure. The physical state of pipemidic acid changed from crystalline to mostly amorphous with its incorporation in microspheres, as shown by x-ray diffractometry and differential scanning calorimetry. No differences were observed in the physical state of pipemidic acid and in microsphere shape and surface between different size fractions of microspheres, prepared with different amounts of magnesium stearate. Additionally, no correlation between the physical state of the drug in different microspheres and their biopharmaceutical properties was found.

응용 분야 · 3건

개요Magnesium stearate, also called octa decanoic acid, magnesium salt, is a white substance, powder which becomes solid at room temperature. It has the chemical formula Mg(C18H35O2)2. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate melts at about 120 °C, is not soluble in water, and is generally considered safe for human consumption at levels below 2500 mg/kg per day.In 1979, the FDA's Subcommittee on GRAS (generally recognized as safe) Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future.".

용도Magnesium Stearate is the magnesium salt of stearic acid which functions as a lubricant, binder, emulsifier, and anticaking agent. it is a white powder that is insoluble in water. it is used as a lubricant or die release in tableting pressed candies and is also used in sugar- less gum and mints.

일반 설명Magnesium stearate (Mg-St) is the magnesium salt of stearic acid. Its anhydrate, dihydrate and trihydrate forms have been prepared. The tabletting of the blends of magnesium stearate and lactose granules has been described. The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined. Mg-St is widely used lubricant in pharmaceutical industry. It also plays a role in delaying the process of dissolution. Its detection in tablets by laser-induced breakdown spectroscopy has been proposed.

제조 방법

Magnesium stearate is created by the reaction of sodium stearate with magnesium sulfate.

생산 방법Magnesium stearate is prepared either by the interaction of aqueous solutions of magnesium chloride with sodium stearate or by the interaction of magnesium oxide, hydroxide, or carbonate with stearic acid at elevated temperatures.

상·하류 제품 정보

상류 원료

1,2,3-프로페인트라이일 옥타데칸산염스테아르산Fatty acid mixture수산화나트륨산화마그네슘황산마그네슘황산마그네슘(7수화물)염화마그네슘

하류 제품

칸타리딘naphtha steam reforming catalystsBILE SALTS
추가 설명 · 5건

순도시험(1) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다. (2) 염화물 : 이 품목 5g을 취하여 환저플라스크에 넣고, 과산화물을 함유하고 있지 않은 디에틸에테르 50mL , 묽은질산 20mL 및 물 20mL를 가한 다음, 환류냉각기를 장착하고 완전히 녹을 때 까지 가열한다. 냉각한 다음, 플라스크의 내용물을 분액깔대기에 옮기고 흔들어 섞은 후, 방치하여 수층을 분취한다. 디에틸에테르층을 물 4mL로 2회 추출하여 추출액을 합하고, 디에틸에테르 15mL로 세정한 다음 물을 가하여 정확히 50mL로 한 액을 시험용액으로 한다. 시험용액 10mL를 취하여 염화물시험법에 따라 시험할 때, 그 양은 0.02N 염산 1.4mL에 대응하는 양 이하이어야 한다(0.10% 이하). (3) 황산염 : 순도시험 (2)의 시험용액 10mL를 취하여 황산염시험법에 따라 시험할 때, 그 양은 0.02N 황산 10.2mL에 대응하는 양 이하이어야 한다(1.0% 이하).

확인시험(1) 이 품목 1g에 염산(1→6)을 가하여 가열하고 식힐 때, 상층에는 지방산층이 뜨고 하층의 수용액은 확인시험법 중 마그네슘염의 반응을 나타낸다. (2) 이 품목 25g을 뜨거운 물 200mL와 혼합하고 묽은황산 60mL를 가하고 자주 저어 주면서 투명한 상층액이 분리될 때까지 가열한 다음 황산이온이 없을 때까지 뜨거운 물로 충분히 세척하고 작은 비이커에 옮겨 증기욕상에서 지방산이 투명하게 될 때까지 수분을 분리시키고 방치한 후 물층은 버리고 지방산층은 가열용융하여 여과한 후 105℃에서 20분간 건조시키고 응고점시험법에 따라 시험할 때, 54℃이상이어야 한다.

정량법이 품목 약 1g을 정밀히 달아 0.1N 염산 50mL를 가하고 때때로 물을 보충하면서 30분간 끓인다. 이를 식힌 후 여과하여 여액이 산성이 나타나지 않을 때까지 충분히 씻고 씻은 액을 여액과 합하여 1N 수산화나트륨용액으로 중화한 다음 이를 시험용액으로 하여 0.05M 이.디.티.에이.용액 30mL, 암모니아․염화암모늄완충액 5mL 및 에리오크롬블랙시액 0.15mL를 가하고 액의 색이 청색이 될 때까지 0.05M 이.디.티.에이.용액으로 적정한다.0.05M 이.디.티.에이.용액 1mL ＝ 2.015mg MgO

정의이 품목은 스테아린산 및 팔미틴산의 마그네슘염의 혼합물이다.

정의Mg(C18H35O2)2 or with one H2O. Technical grade contains small amounts of the oleate and 7% magnesium oxide, MgO.