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Ammonium formate → 1-(4-Fluoro-phenyl)-4-hydroxy-3-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

HRID 642237
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HRID 642237 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:29])=[C:8]2[C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:13](Br)[N:12]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[C:9]2=[CH:10][N:11]=1)=[O:5])[CH3:2].C([O-])=O.[NH4+]>CCOC(C)=O.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:29])=[C:8]2[C:14]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)=[CH:13][N:12]([C:22]3[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=3)[C:9]2=[CH:10][N:11]=1)=[O:5])[CH3:2]
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참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 684282762-bromo-1-(4-fluoro-phenyl)-4-hydroxy-3-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

생성물 1

HCID 684282261-(4-Fluoro-phenyl)-4-hydroxy-3-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 2-bromo-1-(4-fluoro-phenyl)-4-hydroxy-3-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (514 mg, 1.13 mmol), 10% Pd—C (80 mg), and ammonium formate (1.42 g, 22.6 mmol) in EtOAc (15 mL) was refluxed for two days; then the catalysts were filtered off, the filtrate was concentrated, the left residue was purified on column to give the desired title product, ESI MS (m/z): 377 (M+H+).

후처리

  1. temperaturewas refluxed for two days
  2. filtrationthen the catalysts were filtered off
  3. concentrationthe filtrate was concentrated
  4. customthe left residue was purified on column

출처 및 근거

ORD 기록
ord-a3f505ea38bc425b928cfdf911ecd6ec
출처 데이터셋
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07696223B2

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