1-Benzyl-1H-pyrazole-4-boronic acid → 2-(1-Benzyl-1h-pyrazol-4-yl)-4-{[(2,4-dimethoxy-benzyl)-ethoxycarbonylmethyl-amino]-methyl}-thiazole-5-carboxylic acid ethyl ester

HRID 642394

반응식

HRID 642394 반응식
[CH2:1]([O:3][C:4]([C:6]1[S:10][C:9](Br)=[N:8][C:7]=1[CH2:12][N:13]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=1[O:29][CH3:30])[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:5])[CH3:2].[CH2:31]([N:38]1[CH:42]=[C:41](B(O)O)[CH:40]=[N:39]1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH2:1]([O:3][C:4]([C:6]1[S:10][C:9]([C:41]2[CH:40]=[N:39][N:38]([CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH:42]=2)=[N:8][C:7]=1[CH2:12][N:13]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=1[O:29][CH3:30])[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 33528811-Benzyl-1H-pyrazole-4-boronic acidHCID 684264542-Bromo-4-{[(2,4-dimethoxy-benzyl)-ethoxycarbonylmethyl-amino]-methyl}-thiazole-5-carboxylic acid ethyl ester

생성물 1

HCID 684283562-(1-Benzyl-1h-pyrazol-4-yl)-4-{[(2,4-dimethoxy-benzyl)-ethoxycarbonylmethyl-amino]-methyl}-thiazole-5-carboxylic acid ethyl ester

실험 절차

Prepared from 2-bromo-4-{[(2,4-dimethoxy-benzyl)-ethoxycarbonylmethyl-amino]-methyl}-thiazole-5-carboxylic acid ethy ester, example 81(b), and 1-benzyl-1H-pyrazole-4-boronic acid under conditions analogous to experimental example 81(c). MS: (+) m/z 579.4 (M+1).

출처 및 근거

ORD 기록
ord-aa1431426e2943b1ae653397f8acf1d7
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696223B2

연결된 노트

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