N-bromobutanimide → 4-Acetoxy-1-benzyl-3-bromo-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

HRID 642469노트

반응식

HRID 642469 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:7]([O:24][C:25](=[O:27])[CH3:26])=[C:8]2[CH:16]=[CH:15][N:14]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])[CH3:2].C1C(=O)N([Br:35])C(=O)C1>CC#N>[CH2:1]([O:3][C:4]([C:6]1[C:7]([O:24][C:25](=[O:27])[CH3:26])=[C:8]2[C:16]([Br:35])=[CH:15][N:14]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 684278514-Acetoxy-1-benzyl-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

생성물 1

HCID 684282184-Acetoxy-1-benzyl-3-bromo-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester수율 84.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
90 °C

실험 절차

A mixture of 4-acetoxy-1-benzyl-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (225 mg), NBS (116 mg) in MeCN (3 mL) in a closed vial was heated at 90° C. overnight. Then the solvent was removed, the residue was purified with column to give the desired product (232 mg). The title compound, ESI MS (m/z): 442 (M+H)+.

후처리

  1. customThen the solvent was removed
  2. customthe residue was purified with column

출처 및 근거

ORD 기록
ord-39ceac0f80ef48af84630b77e02ef5c7
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696223B2

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