Ammonium formate → 7-Cyano-1-(2-fluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

HRID 642518노트

반응식

HRID 642518 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:27])=[C:8]2[C:16](Br)=[C:15](Br)[N:14]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[F:26])[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])[CH3:2].C([O-])=O.[NH4+]>[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:27])=[C:8]2[CH:16]=[CH:15][N:14]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[F:26])[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 2723923Ammonium formateHCID 684281812,3-Dibromo-7-cyano-1-(2-fluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

생성물 1

HCID 684268627-Cyano-1-(2-fluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Prepared in analogy to that of Example 6(a) from 2,3-dibromo-7-cyano-1-(2-fluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, ammonium formate and Pd/C. The title compound, ESI MS (m/z): 340 (M+H)+.

출처 및 근거

ORD 기록
ord-01db562b639748fdadca0bb10728d2d5
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696223B2

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