Benzoyl chloride → 6-Oxobicyclo[3.2.0]heptan-2-yl benzoate

HRID 642745

반응식

HRID 642745 반응식
[OH:1][CH:2]1[CH2:8][CH2:7][CH:6]2[CH:3]1[CH2:4][C:5]2=[O:9].CCN(CC)CC.[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(Cl)Cl>[C:17]([O:1][CH:2]1[CH2:8][CH2:7][CH:6]2[CH:3]1[CH2:4][C:5]2=[O:9])(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 134438072-Hydroxybicyclo[3.2.0]heptan-6-one

생성물 1

HCID 592595756-Oxobicyclo[3.2.0]heptan-2-yl benzoate수율 86.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a stirred solution of compound 1G (1.9 g, 15.1 mmol) in CH2Cl2 (10 mL) at 0° C. under nitrogen were added Et3N (3.1 mL, 22.2 mmol) and benzoyl chloride (2.33 g, 16.6 mmol). The reaction was stirred at 0° C. for 60 min and RT for 30 min, then quenched with water. The product was extracted with CH2Cl2, the organics were washed with saturated aqueous NaHCO3, dried over Na2SO4, and concentrated. Purification by silica gel chromatography (5% EtOAc in hexanes) provide the title compound (3 g).

후처리

  1. customquenched with water
  2. extractionThe product was extracted with CH2Cl2
  3. washthe organics were washed with saturated aqueous NaHCO3
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated
  6. customPurification by silica gel chromatography (5% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-702fd5351b1f45cbbfb37422ed9dc037
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696241B2

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