2,2,2,4'-Tetrafluoroacetophenone → 2,2,2-Trifluoro-1-(4-fluorophenyl)ethanol

HRID 642892

반응식

HRID 642892 반응식
[F:1][C:2]([F:13])([F:12])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>CO>[F:13][C:2]([F:1])([F:12])[CH:3]([C:5]1[CH:6]=[CH:7][C:8]([F:11])=[CH:9][CH:10]=1)[OH:4]

참가 물질

4

반응물 2

HCID 695642,2,2,4'-TetrafluoroacetophenoneHCID 4311764Sodium borohydride

생성물 1

HCID 111482462,2,2-Trifluoro-1-(4-fluorophenyl)ethanol수율 111.9%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

To a stirred solution of 2,2,2,4′-tetrafluoroacetophenone (10 g, 52.1 mmol) in methanol (50 mL) was added NaBH4 (0.98 g, 26.5 mmol) at 0° C. After stirring at 25° C. for 2 h, the reaction mixture was quenched by adding 1N HCl (100 mL) and then extracted with ethyl ether. The ether extract was washed with brine, dried with MgSO4, and concentrated to give 2,2,2-trifluoro-1-(4-fluorophenyl)ethanol (11.32 g) which was used in next step without further purification.

후처리

  1. customthe reaction mixture was quenched
  2. additionby adding 1N HCl (100 mL)
  3. extractionextracted with ethyl ether
  4. extractionThe ether extract
  5. washwas washed with brine
  6. dry with materialdried with MgSO4
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c19864ec4263411ab3e3e915a509ca58
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696250B2

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