4-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole → (1-(4-iodophenyl)-1H-pyrazol-4-yl)methanamine

HRID 643029노트

반응식

HRID 643029 반응식
[N:1]([CH2:4][C:5]1[CH:6]=[N:7][N:8]([C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][CH:11]=2)[CH:9]=1)=[N+]=[N-]>CO.[Ni]>[I:16][C:13]1[CH:12]=[CH:11][C:10]([N:8]2[CH:9]=[C:5]([CH2:4][NH2:1])[CH:6]=[N:7]2)=[CH:15][CH:14]=1

참가 물질

4

반응물 1

HCID 866140084-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole

생성물 1

HCID 68507921(1-(4-iodophenyl)-1H-pyrazol-4-yl)methanamine수율 81.2%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A mixture of 4-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole (530 mg, 1.63 mmol) and Ra—Ni (50% aq. slurry, 200 mg) in MeOH (3 mL) was hydrogenated under balloon H2 for 1 hr. It was filtered through celite. The filtrate was concentrated in vacuo to give (1-(4-iodophenyl)-1H-pyrazol-4-yl)methanamine (396 mg).

후처리

  1. filtrationIt was filtered through celite
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-9d927dbb347f4c57b57d9a8092397621
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696352B2

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