HCID 11449562, 화합물 → HCID 72806257, 화합물
반응식
[CH3:1][N:2]([CH3:22])[C:3]([CH2:5][CH2:6][CH2:7][C:8]#[C:9][C:10]1[CH:11]=[C:12]([CH:19]=[CH:20][CH:21]=1)[C:13]([NH:15][CH2:16][CH2:17][F:18])=[O:14])=[O:4]>[Ni]>[CH3:22][N:2]([CH3:1])[C:3]([CH2:5][CH2:6][CH2:7][CH:8]=[CH:9][C:10]1[CH:11]=[C:12]([CH:19]=[CH:20][CH:21]=1)[C:13]([NH:15][CH2:16][CH2:17][F:18])=[O:14])=[O:4]참가 물질
3
실험 절차
Hydrogenation of 3-(5-dimethylcarbamoyl-pent-1-ynyl)-N-(2-fluoro-ethyl)benzamide (26)(0.040 g, 0.13 mmol) using BER/Ni catalyst gave 40% 28, and 55% of starting material. The mixture was separated by reverse-phase HPLC chromatography (30% acetonitrile/70% water 20 min isocratic program) to give 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-fluoro-ethyl)-benzamide 28 (5 mg).
출처 및 근거
- ORD 기록
- ord-bacda5dcd6924810bdf8174c73cd644d
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07696382B2
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