Hydrochloric Acid → Phthalylglycine aldehyde

HRID 643074

반응식

HRID 643074 반응식
C(O[C:4]1([O:14]CC)[NH:8][C:7](=[O:9])[C:6]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:5]12)C.Cl.[O:18]1CC[CH2:20][CH2:19]1>>[O:14]=[C:4]1[C:5]2[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:7](=[O:9])[N:8]1[CH2:20][CH:19]=[O:18]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 66899166Phthalimide diethylacetal

생성물 1

HCID 76201Phthalylglycine aldehyde

반응 조건

온도
75 °C

실험 절차

To a solution of phthalimide diethylacetal (15 g) in tetrahydrofuran (THF) (30 mL) was added 10% aqueous HCl (18 mL). After heating at 75° C. for 5 hrs, the solution was allowed to cool to room temperature, and ethyl acetate was separated and dried over magnesium sulfate (MgSO4). The solution was filtered and evaporated to provide 11.2 g of the titled compound.

후처리

  1. temperatureto cool to room temperature
  2. customethyl acetate was separated
  3. dry with materialdried over magnesium sulfate (MgSO4)
  4. filtrationThe solution was filtered
  5. customevaporated

출처 및 근거

ORD 기록
ord-d36663426f704177947eda52ba39cdbd
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696226B2

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