Bromine → 4-Bromo-2-methyl-6-(trifluoromethyl)aniline

HRID 643136노트

반응식

HRID 643136 반응식
[Br:1]Br.[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:5]=1[NH2:14].C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[Br:1][C:8]1[CH:7]=[C:6]([C:10]([F:11])([F:12])[F:13])[C:5]([NH2:14])=[C:4]([CH3:3])[CH:9]=1

참가 물질

5

반응물 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 133182332-Amino-3-methylbenzotrifluoride

생성물 1

HCID 674070344-Bromo-2-methyl-6-(trifluoromethyl)aniline

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

Under a nitrogen atmosphere a solution of 11.0 mL (214 mmol) bromine in 100 mL chloroform was added dropwise to a solution of 35.8 g (204 mmol) 2-methyl-6-trifluoromethyl-phenylamine in 350 mL chloroform and after the end of the addition the reaction mixture was stirred for 3 h at RT. Saturated NaHCO3 solution was added with stirring, the mixture was stirred for a further 20 min at RT, the organic phase was separated off and dried over Na2SO4. After the desiccant and solvent had been eliminated the product was obtained as an oil, which was further reacted without purification.

후처리

  1. additionafter the end of the addition the reaction mixture
  2. stirringwith stirring
  3. stirringthe mixture was stirred for a further 20 min at RT
  4. customthe organic phase was separated off
  5. dry with materialdried over Na2SO4
  6. customwas obtained as an oil, which
  7. customwas further reacted without purification

출처 및 근거

ORD 기록
ord-1143ad61be9442f0bbd388ad9f25f9ec
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696209B2

반응 노트

불러오는 중…