Sodium borohydride → (2-Fluoro-4-nitrophenyl)methanol

HRID 64336노트

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HRID 64336 반응식
[F:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>CO>[F:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 45629192-Fluoro-4-nitrobenzaldehyde

생성물 1

HCID 17981733(2-Fluoro-4-nitrophenyl)methanol수율 99%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-fluoro-4-nitrobenzaldehyde (1.0 g, 5.92 mmol) in CH3OH (10 mL) was added NaBH4 (814 mg, 22 mmol). After stirring at RT for 15 min, the mixture was concentrated. The residue was partitioned between 100 mL of EA and 100 mL of brine. The combined organic layers were washed with brine (100 mL×2), dried over Na2SO4, and concentrated to afford 1.0 g of (2-fluoro-4-nitrophenyl) methanol (99%) as a red solid. MS (ESI) m/e [M+1]+ 172.0.

후처리

  1. concentrationthe mixture was concentrated
  2. customThe residue was partitioned between 100 mL of EA and 100 mL of brine
  3. washThe combined organic layers were washed with brine (100 mL×2)
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-cf1bd06299bd4455957dcef8c4381f7e
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447106B2

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