Methyl iodide → 5-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester

HRID 643685

반응식

HRID 643685 반응식
I[CH3:2].[NH2:3][C:4]1[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][N:7]=[C:6]([SH:15])[N:5]=1>CN(C)C=O>[NH2:3][C:4]1[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][N:7]=[C:6]([S:15][CH3:2])[N:5]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 178469867HCID 178469867, 화합물

생성물 1

HCID 2226665-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Iodomethane (2.6 g, 18 mmol) was added to the hot solution (˜50° C.) of ethyl 4-amino-2-mercaptopyrimidine-5-carboxylate (3.0 g, 15 mmol) in N,N-dimethylformamide (150 mL) and stirred at room temperature for 20 min. Solvent was removed in vacuo and the solid residue was washed by water. After dried in vacuo, desired product was obtained as a white solid (3.1 g, 97%).

후처리

  1. customSolvent was removed in vacuo
  2. washthe solid residue was washed by water
  3. customAfter dried in vacuo

출처 및 근거

ORD 기록
ord-53fa3e6a94484237aa6b32775fcfe148
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700622B2

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