Lithium Hydroxide → 4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid

HRID 643686

반응식

HRID 643686 반응식
[NH2:1][C:2]1[C:7]([C:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[OH-].[Li+]>CO.O>[NH2:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[C:4]([S:11][CH3:12])[N:3]=1

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 225621764-Amino-2-methylsulfanyl-5-pyrimidinecarboxylate

생성물 1

HCID 221347384-Amino-2-(methylthio)pyrimidine-5-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

4-Amino-2-methylmercaptopyrimidine-5-carboxylate (1.5 g, 7 mmol) was suspended in the solution of lithium hydroxide (340 mg, 14 mmol) in methanol (10 mL) and water (5 mL) and stirred at 60° C. over night. Solid was filtered out and filtrate was collected. Solvent was removed under reduce pressure. Residue was dissolved in water and was neutralized by acetic acid till pH˜5. White solid thus formed was filtered out and dried in vacuo (0.72 g, 55%).

후처리

  1. filtrationSolid was filtered out
  2. customfiltrate was collected
  3. customSolvent was removed
  4. dissolutionResidue was dissolved in water
  5. customWhite solid thus formed
  6. filtrationwas filtered out
  7. customdried in vacuo (0.72 g, 55%)

출처 및 근거

ORD 기록
ord-dfeec2a9bec54db3837328b45d7212e2
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700622B2

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