홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Acetic Acid → HCID 68493021, 화합물

HRID 643824
노트
인쇄 미리보기

반응식

HRID 643824 반응식
C([O:3][C:4]([C:6]1([NH:11][C:12]([CH:14]2[CH2:18][CH:17]([O:19][C:20]3[C:29]4[C:24](=[CH:25][C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH:21]=3)[CH2:16][NH:15]2)=[O:13])[CH2:8][CH:7]1[CH:9]=[CH2:10])=[O:5])C.[Li+].[OH-].CC(O)=O.C1(C)C=CC=CC=1>C1COCC1.CO>[CH3:31][O:30][C:26]1[CH:25]=[C:24]2[C:29]([C:20]([O:19][C@H:17]3[CH2:16][NH:15][C@H:14]([C:12]([NH:11][C@:6]4([C:4]([OH:5])=[O:3])[CH2:8][C@H:7]4[CH:9]=[CH2:10])=[O:13])[CH2:18]3)=[CH:21][C:22]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)=[N:23]2)=[CH:28][CH:27]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 1140TolueneHCID 3939Lithium HydroxideHCID 207653161-{[4-(7-Methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

생성물 1

HCID 68493021HCID 68493021, 화합물수율 104.5%

시약·촉매·용매 1

HCID 21899815
MeOH tetrahydrofuran
용매

실험 절차

To a solution of compound 6 (0.067 mmol) in THF-MeOH 2:3 (2 ml) was added 1M LiOH 10 equiv. The solution was kept at 50° C. for 2.5 hrs. After cooling to RT, HOAc 20 eq. was added followed by toluene (2 ml) and then concentrated to dryness. The residue was taken up in DCM and filtered form the salts which gave the title compound (0.07 mmol). Purity >95% by HPLC M+H+ 474.

후처리

  1. concentrationconcentrated to dryness
  2. filtrationfiltered form the salts which

출처 및 근거

ORD 기록
ord-b38640082de94532bb937d0237cc7c65
출처 데이터셋
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07700552B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트