Sodium Hydroxide → HCID 59263290, 화합물

HRID 643992노트

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HRID 643992 반응식
C[O:2][C:3](=[O:43])[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[N:11]([S:19]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][C:31]2[N:32]=[C:33]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[O:34][C:35]=2[CH3:36])=[CH:24][CH:23]=1)(=[O:21])=[O:20])C(OC(C)(C)C)=O.[OH-].[Na+]>O1CCOCC1>[Cl:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:43])=[O:2])=[C:5]([NH:11][S:19]([C:22]2[CH:23]=[CH:24][C:25]([O:28][CH2:29][CH2:30][C:31]3[N:32]=[C:33]([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)[O:34][C:35]=3[CH3:36])=[CH:26][CH:27]=2)(=[O:20])=[O:21])[CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 685793864-Chloro-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzenesulfonyl-(t-butoxycarbonyl)amino}-benzoic acid methyl ester

생성물 1

HCID 59263290HCID 59263290, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
90 °C

실험 절차

A solution of the title G compound, 4-chloro-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzenesulfonyl-(t-butoxycarbonyl)amino}-benzoic acid methyl ester (300 mg, 0.48 mmol) in dioxane (5 mL) to which 2.4 mL of 1 N aqueous NaOH is added is heated at 90° C. for 3 h. The mixture is concentrated under vacuum, acidified with 1 N aqueous HCl, and extracted twice with EtOAc. The organic solution is dried over anhydrous magnesium sulfate, filtered and concentrated to give a crude product which is triturated with DCM. The solid is collected by filtration to afford 4-chloro-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzenesulfonyl-amino}-benzoic acid: m.p. 223-225° C.; ESI-MS 513 [M+1]+.

후처리

  1. concentrationThe mixture is concentrated under vacuum
  2. extractionextracted twice with EtOAc
  3. dry with materialThe organic solution is dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customto give a crude product which
  7. customis triturated with DCM
  8. filtrationThe solid is collected by filtration

출처 및 근거

ORD 기록
ord-51ab0df35d444a858001de495f719a74
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700637B2

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