N-(5-chloropyridin-2-yl)-2-nitrobenzamide → 2-amino-N-(5-chloropyridin-2-yl)benzamide

HRID 644162

반응식

HRID 644162 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:19])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N+:16]([O-])=O)=[N:6][CH:7]=1>C1COCC1.C(OCC)(=O)C.[Ni]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:19])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH2:16])=[N:6][CH:7]=1

참가 물질

5

반응물 1

HCID 766647N-(5-chloropyridin-2-yl)-2-nitrobenzamide

생성물 1

HCID 219063812-amino-N-(5-chloropyridin-2-yl)benzamide수율 84.1%

시약·촉매·용매 3

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of N-(5-chloropyridin-2-yl)-2-nitrobenzamide (2 g, 7.2 mmol) in THF (50 mL) and ethyl acetate (50 mL) was added Raney Ni (0.2 g) and the mixture was placed under hydrogen (4.1 bar) in a high pressure apparatus. After shaking overnight, the mixture was filtered and concentrated in vacuo and purified by flash chromatography to give 1.5 g (83%) of an off-white solid.

후처리

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated in vacuo
  3. custompurified by flash chromatography

출처 및 근거

ORD 기록
ord-2f54972e7b2044f49cdedece1b2789a0
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700628B2

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