Dimethyl Sulfoxide → HCID 68537107, 화합물

HRID 644268노트

반응식

HRID 644268 반응식
F[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:12][CH2:13][O:14][CH3:15])[CH:3]=1.CS(C)=O.[CH2:20]([S-:22])[CH3:21].[Na+]>O>[CH2:20]([S:22][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:12][CH2:13][O:14][CH3:15])[CH:3]=1)[CH3:21]

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 4459711Sodium ethanethiolateHCID 58437341Methyl 4-fluoro-2-(methoxymethoxy)benzoate

생성물 1

HCID 68537107HCID 68537107, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of methyl 4-fluoro-2-(methoxymethoxy)benzoate (10.6 g, 50 mmol) and DMSO (20 mL), under nitrogen, was added sodium ethanethiolate (5.8 g, 55 mmol) in portions. The exothermic reaction was stirred for 19 h, diluted with water, and extracted with ethyl acetate. The organic layer was concentrated; and the residue was dissolved in ether, filtered through diatomaceus earth, and concentrated to give intermediate methyl 4-(ethylthio)-2-(methoxymethoxy)benzoate.

후처리

  1. customThe exothermic reaction
  2. extractionextracted with ethyl acetate
  3. concentrationThe organic layer was concentrated
  4. dissolutionand the residue was dissolved in ether
  5. filtrationfiltered through diatomaceus earth
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d0e303483cf64d2d85a34241994a09d2
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700628B2

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