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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Lithium hydroxide, monohydrate → 3-(3,4-Diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid

HRID 644301
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HRID 644301 반응식
[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH:17][C:18]([N:20]2[CH2:25][CH2:24][CH:23]([N:26]3[CH2:32][CH2:31][C:30]4[CH:33]=[CH:34][CH:35]=[CH:36][C:29]=4[NH:28][C:27]3=[O:37])[CH2:22][CH2:21]2)=[O:19])[C:13]([O:15]C)=[O:14])[CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH3:2].O.[OH-].[Li+]>CCO>[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH:17][C:18]([N:20]2[CH2:21][CH2:22][CH:23]([N:26]3[CH2:32][CH2:31][C:30]4[CH:33]=[CH:34][CH:35]=[CH:36][C:29]=4[NH:28][C:27]3=[O:37])[CH2:24][CH2:25]2)=[O:19])[C:13]([OH:15])=[O:14])[CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH3:2]
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참가 물질

4

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 22184617Methyl 3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionate

생성물 1

HCID 221845783-(3,4-Diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

26 g of the crude product described in 3d) were dissolved in 200 mL EtOH, combined with 2.3 g (55 mmol) of lithium hydroxide hydrate and stirred overnight at RT. The reaction solution was concentrated by evaporation in vacuo, the residue was taken up with water, extracted with diethyl ether, acidified with citric acid solution and exhaustively extracted with EtOAc. The combined organic phases were dried over MgSO4 and evaporated down in vacuo.

후처리

  1. concentrationThe reaction solution was concentrated by evaporation in vacuo
  2. extractionextracted with diethyl ether
  3. extractionexhaustively extracted with EtOAc
  4. dry with materialThe combined organic phases were dried over MgSO4
  5. customevaporated down in vacuo

출처 및 근거

ORD 기록
ord-0b404fcbc2144f2c9609e5df2725c7c3
출처 데이터셋
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07700589B2

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