4,4-Difluoro-1′-(phenylmethyl)-1,4′-bipiperidine → 4,4-difluoro-1,4'-bipiperidine

HRID 644330노트

반응식

HRID 644330 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][C:17]([F:21])([F:20])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.Cl.[Pd]>[F:21][C:17]1([F:20])[CH2:18][CH2:19][N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:15][CH2:16]1

참가 물질

6

반응물 2

HCID 685813714,4-Difluoro-1′-(phenylmethyl)-1,4′-bipiperidineHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 534187744,4-difluoro-1,4'-bipiperidine

시약·촉매·용매 3

HCID 313Hydrochloric Acid촉매HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 2.8 g (9.5 mmol) 1′-benzyl-4,4-difluoro-[1,4′]bipiperidinyl in 300 mL MeOH was hydrogenated in the presence of 1.2 g Pd/C (10%) at 50° C. and 50 psi hydrogen pressure with the addition of a few drops of 1 M HCl until the calculated volume of hydrogen had been taken up. The catalyst was filtered off and the filtrate was evaporated down under reduced pressure. The residue was triturated with diisopropylether, suction filtered and dried.

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated down under reduced pressure
  3. customThe residue was triturated with diisopropylether, suction
  4. filtrationfiltered
  5. customdried

출처 및 근거

ORD 기록
ord-b9641564546c46fb8ebb21f5e72aff44
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700589B2

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