Sulfuric Acid → 2-(Acetyloxy)-5-chlorobenzoic acid
반응식
S(=O)(=O)(O)O.[Cl:6][C:7]1[CH:15]=[C:11]([C:12]([OH:14])=[O:13])[C:10]([OH:16])=[CH:9][CH:8]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([O:16][C:10]1[CH:9]=[CH:8][C:7]([Cl:6])=[CH:15][C:11]=1[C:12]([OH:14])=[O:13])(=[O:19])[CH3:18]참가 물질
4
실험 절차
Concentrated sulfuric acid (0.08 mL) was added slowly to a mixture of 5-chlorosalicylic acid (13.35 g, 77 mmol) and acetic anhydride (20 mL). After the reaction mixture was solidified, it was poured into ice water and extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous sodium sulfate. The residue obtained by evaporation of the solvent under reduced pressure was washed with n-hexane under suspension to give the title compound (15.44 g, 93.0%) as a white crystal.
후처리
- extractionextracted with ethyl acetate
- washThe organic layer was washed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- customThe residue obtained by evaporation of the solvent under reduced pressure
- washwas washed with n-hexane under suspension
출처 및 근거
- ORD 기록
- ord-f31a00664c4e479686f57363ead5e31a
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07700655B2
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