Sulfuric Acid → 2-(Acetyloxy)-5-chlorobenzoic acid

HRID 644392

반응식

HRID 644392 반응식
S(=O)(=O)(O)O.[Cl:6][C:7]1[CH:15]=[C:11]([C:12]([OH:14])=[O:13])[C:10]([OH:16])=[CH:9][CH:8]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([O:16][C:10]1[CH:9]=[CH:8][C:7]([Cl:6])=[CH:15][C:11]=1[C:12]([OH:14])=[O:13])(=[O:19])[CH3:18]

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 94475-Chlorosalicylic Acid

생성물 1

HCID 28208132-(Acetyloxy)-5-chlorobenzoic acid수율 93%

실험 절차

Concentrated sulfuric acid (0.08 mL) was added slowly to a mixture of 5-chlorosalicylic acid (13.35 g, 77 mmol) and acetic anhydride (20 mL). After the reaction mixture was solidified, it was poured into ice water and extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous sodium sulfate. The residue obtained by evaporation of the solvent under reduced pressure was washed with n-hexane under suspension to give the title compound (15.44 g, 93.0%) as a white crystal.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe residue obtained by evaporation of the solvent under reduced pressure
  5. washwas washed with n-hexane under suspension

출처 및 근거

ORD 기록
ord-f31a00664c4e479686f57363ead5e31a
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700655B2

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