N-bromobutanimide → 2-Bromo-4,4-dimethyl-3-oxopentanenitrile

HRID 644434노트

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HRID 644434 반응식
[C:1]([CH2:7][C:8]#[N:9])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[Br:10]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:10][CH:7]([C:1](=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3])[C:8]#[N:9]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-

생성물 1

HCID 115864832-Bromo-4,4-dimethyl-3-oxopentanenitrile수율 87.9%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

Pivaloylacetonitrile (1.00 g, 7.99 mmol) was dissolved in carbon tetrachloride (15 mL). N-Bromosuccinimide (1.42 g, 7.99 mmol) was added, and the mixture was refluxed for 15 minutes. After cooling, the insoluble matter was filtered off, and the residue obtained by evaporation of the filtrate under reduced pressure was purified by chromatography on silica gel (n-hexane:ethyl acetate=4:1) to give the title compound (1.43 g, 87.9%) as an yellowish brown oil.

후처리

  1. temperaturethe mixture was refluxed for 15 minutes
  2. temperatureAfter cooling
  3. filtrationthe insoluble matter was filtered off
  4. customthe residue obtained by evaporation of the filtrate under reduced pressure
  5. customwas purified by chromatography on silica gel (n-hexane:ethyl acetate=4:1)

출처 및 근거

ORD 기록
ord-d3a1625a8b3342fd8e3bef5c39b7f0ef
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700655B2

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