Thiourea → 2-amino-4-(tert-butyl)-1,3-thiazole-5-carbonitrile

HRID 644435노트

반응식

Br[CH:2]([C:5](=O)[C:6]([CH3:9])([CH3:8])[CH3:7])[C:3]#[N:4].[NH2:11][C:12]([NH2:14])=[S:13]>>[NH2:14][C:12]1[S:13][C:2]([C:3]#[N:4])=[C:5]([C:6]([CH3:9])([CH3:8])[CH3:7])[N:11]=1

참가 물질

반응물 2

HCID 2723790Thiourea

HCID 115864832-Bromo-4,4-dimethyl-3-oxopentanenitrile

생성물 1

HCID 27685182-amino-4-(tert-butyl)-1,3-thiazole-5-carbonitrile수율 66.3%

실험 절차

Using α-bromo-pivaloylacetonitrile and thiourea as the raw materials, the same operation as the Example 181(1) gave the title compound.

출처 및 근거

ORD 기록: ord-4c6199ff78b24ddc8b4a140d16772ad2
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07700655B2

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