Hexane → 5-Bromo-4-tert-butyl-1,3-thiazol-2-amine

HRID 644439

반응식

HRID 644439 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1.[Br:11]N1C(=O)CCC1=O.CCCCCC>C(Cl)(Cl)(Cl)Cl>[NH2:1][C:2]1[S:3][C:4]([Br:11])=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1

참가 물질

5

반응물 3

HCID 8058HexaneHCID 67184N-bromobutanimideHCID 27342024-tert-Butyl-1,3-thiazol-2-amine

생성물 1

HCID 7291355-Bromo-4-tert-butyl-1,3-thiazol-2-amine수율 93.7%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

2-Amino-4-[(1,1-dimethyl)ethyl]thiazole (compound of Example 181(1); 0.87 g, 5.6 mmol) was dissolved in carbon tetrachloride (9 mL). N-Bromosuccinimide (1.00 g, 5.6 mmol) was added, and the mixture was stirred at room temperature for 1 hour. Hexane was added to the reaction mixture. The insoluble matter was filtered off, and the residue obtained by evaporation of the filtrate under reduced pressure was purified by chromatography on silica gel (hexane:ethyl acetate=2:1) to give the title compound (1.23 g, 93.7%) as an yellowish gray powder.

후처리

  1. filtrationThe insoluble matter was filtered off
  2. customthe residue obtained by evaporation of the filtrate under reduced pressure
  3. customwas purified by chromatography on silica gel (hexane:ethyl acetate=2:1)

출처 및 근거

ORD 기록
ord-7a79036d05b44beabd86e65881402ec7
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700655B2

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