1-(2,5-Difluorophenyl)ethan-1-one → 4-(2,5-Difluorophenyl)-1,3-thiazol-2-amine

HRID 644487

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=O)[CH3:10].[NH2:12][C:13]([NH2:15])=[S:14]>>[NH2:15][C:13]1[S:14][CH:10]=[C:9]([C:3]2[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=2[F:1])[N:12]=1

참가 물질

반응물 2

HCID 747941-(2,5-Difluorophenyl)ethan-1-one

HCID 2723790Thiourea

생성물 1

HCID 20640894-(2,5-Difluorophenyl)-1,3-thiazol-2-amine수율 77.8%

실험 절차

Using 2′,5′-difluoroacetophenone and thiourea as the raw materials, the same operation as the Example 395(1) gave the title compound.

출처 및 근거

ORD 기록: ord-fef72665099a40caaa4b8b16b1184265
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07700655B2

연결된 노트

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