Hydrogen Bromide → Isoindolin-5-ol HCl

반응식

C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6]2.[BrH:12]>>[BrH:12].[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6]2

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 147958725-methoxy-2,3-dihydro-1H-isoindole

생성물 1

HCID 18630974Isoindolin-5-ol HCl수율 93%

실험 절차

5-Methoxyisoindoline (8.34 g, 55.97 mmol) in 48% aqueous hydrobromic acid (100 ml) was stirred and held at reflux for 16 hours. Upon cooling to room temperature the solvent was removed in vacuo to afford 5-hydroxyisoindoline hydrobromide (11.32 g, 93%) as a tan solid. 1H NMR (DMSO-d6) 9.63 (1H, br s), 9.32 (2H, br s), 7.18 (1H, d), 6.79 (1H, d), 6.76 (1H, dd), 4.42 (2H, t), 4.38 (2H, t). MS: [M+H]+ 136.

후처리

temperatureat reflux for 16 hours
customwas removed in vacuo

출처 및 근거

ORD 기록: ord-e03d7e101e884e48b4f77e24dedc5d7a
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07700625B2

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