Hydrochloric Acid → 4-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride

HRID 645475노트

반응식

HRID 645475 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:18][CH2:17][C:16]([F:20])([F:19])[CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>O1CCOCC1>[ClH:21].[F:20][C:16]1([F:19])[CH2:17][CH2:18][N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:15]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 53419023Tert-butyl 4-(3,3-difluoropyrrolidin-1-YL)piperidine-1-carboxylate

생성물 1

HCID 687110244-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4-(3,3-difluoro-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (1.77 mmol) is treated with 4N HCl in 1,4-dioxane (6 mL) and stirred at room temperature for 1 h. The reaction mixture is concentrated in vacuo and the resulting residue is used for the next step without further purification.

후처리

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customthe resulting residue is used for the next step without further purification

출처 및 근거

ORD 기록
ord-a13adcd5765b4148a72afbf3d1f3fbc3
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07704996B2

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