Hydrazine hydrate (1:1) → 2-Phenyl-3-pyrrolidin-1-yl propylamine
반응식
[C:1]1([CH:7]([CH2:20][N:21]2CCCC2)[CH2:8][N:9]2[C:17](=O)[C:16]3[C:11](=CC=CC=3)[C:10]2=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN>C(O)C>[C:1]1([CH:7]([CH2:8][N:9]2[CH2:17][CH2:16][CH2:11][CH2:10]2)[CH2:20][NH2:21])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
4
실험 절차
A solution of 2-(2-phenyl-3-pyrrolidin-1-yl propyl)isoindole-1,3-dione (3 mmol) and hydrazine monohydrate (6 mmol) in ethanol (10 mL) is refluxed for 3.5 h. The reaction mixture is cooled and filtered through celite. The filtrate is concentrated in vacuo to give the title compound, which is directly used for the next reaction without further purification.
후처리
- temperatureThe reaction mixture is cooled
- filtrationfiltered through celite
- concentrationThe filtrate is concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-dafb20952a7f490f84f56ba067909a95
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07704996B2
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